Spermatogenesis relies on the interplay between central and testicular hormonal factors. The hypothalamus releases gondaotropin-releasing hormone (GnRH), which causes the anterior pituitary to secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Inside the testicle, LH stimulates Leydig cells to produce testosterone, and FSH acts on Sertoli cells to produce spermatogonia.1 Endocrinopathies are the primary etiology in a minority (<3%) of the cases of male infertility and can be divided into cases of hormonal deficiency and hormonal excess.
aromatase inhibitor, clomiphene citrate, estradiol, follicle stimulating hormone, human chorionic hypergonadotropic hypogonadism, hypogonadotropic hypogonadism, Kallman syndrome, Klinefelter syndrome, luteinizing hormone, prolactin, testosterone
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