- Peyronie's Disease: Epidemiology, Pathophysiology, Evaluation - Sexual Medicine and Andrology | Urology Core Curriculum
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1. Introduction
2. Etiology and Risk Factors
3. Pathophysiology
4. Clinical Presentation
5. Impact of PD
6. Patient Evaluation
6.1 History
6.2 Physical Examination
6.3 Deformity Assessment
6.4 Laboratory Assessment
6.5 Imaging & Adjunctive Testing
7. Educational Material
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Peyronie's Disease: Epidemiology, Pathophysiology, Evaluation

Akanksha Mehta, MD, MS
Helen L. Bernie, MD
Last Updated:
Wednesday, December 23, 2020


Peyronie’s, curved penis, bent penis, penile plaque, penile pain, curved erection

1. Introduction

Peyronie’s disease (PD) is a progressive condition resulting in fibrous plaque formation within the tunica albuginea (TA) of the penis, in some cases leading to penile deformity such as shortening, narrowing, and/or curvature, pain with intercourse, and distress.1 The incidence of PD is estimated to be 22.4 to 25.6 cases per 100,000 men. The condition most commonly presents in men 50 to 59 years old with an average age of presentation of 55 years.2,3 Despite the higher incidence in older men, men of all ages from adolescence to late adulthood may be affected.4,5,6 The prevalence of PD ranges from 0.4% to 13%, although this is likely an underestimation due to underreporting bias among men reluctant to discuss the condition.7

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