Abstract: PD49-02
Sources of Funding: none

Introduction

To develop and validate a preoperative radiological assessment tool for predicting complications following inguinal lymph node dissection (ILND) in penile cancer patients. _x000D_

Methods

Patients treated at Fudan University Shanghai Cancer Center (n=175) and Moffitt Cancer Center (n=28) were used for prediction assessment and repetition, respectively. The ILN complexity score (ILCS) included 5 radiological features of ILNs and surrounding adipose tissue. A tertiary (low/moderate/high) classification was assigned according to the sum score. Postoperative complications were graded according to the Clavien-Dindo system. Logistic regression analyses were used to assess the odd ratios (ORs) of the ILCS for predicting overall and major (grade?2) complications._x000D_

Results

In the primary cohort, overall and major complications were observed in 47.4% and 20.5% of patients, respectively. Controlling for covariates, the moderate and high scores had 2.73 (p=0.02) and 4.61-fold (p=0.01) increased risks of overall complications compared with the low score. For predicting major complications, the adjusted OR was 3.48 for the moderate score (p=0.02), and 17.01 for the high score (p<0.01), using the low score as a reference. The predictive accuracy of the ILCS for overall and major complications was 0.63 (0.56-0.70) and 0.73 (0.64-0.82), respectively. In the repetition cohort, the ILCS was significantly associated with major complications (OR=17.33, p=0.02) and showed a predictive accuracy of 0.79 (0.64-0.93)._x000D_

Conclusions

Using structured radiological measurements of the inguinal nodal basin, the ILCS provided accurate risk estimation of overall and major complications after ILND for penile cancer._x000D_

Funding

none