Abstract: PD45-02
Sources of Funding: PCEC

Introduction

To validate the MADS questionnaire which was developed to identify men with hypogonadism.

Methods

A simplified instrument was developed to identify men with hypogonadism and was introduce in 2014 utilizing the Prostate Conditions Education Council (PCEC) Screening Questionnaire which was designed to collect information on age, race (AA-African American, W-white and H-Hispanic), presence on adult onset diabetes (AODM), Exercise frequency (Ex), overweight status (OS) and erectile function (EF) (Stone, NN et al, J. of Mens Health,11,2014). Based on regression analysis of 5071 men a number of groups were identified as being associated with a >60% likelihood of having a testosterone (T)< 300 ng/dL (Figure). The 3 questions comprising the MADS questionnaire were added to the PCEC questionnaire and utilized during Prostate Cancer Awareness Weeks (PCAW) in 2014 and 2015 to validate them. Associations between the questions and T < 300 ng/dL were tested by chi-square analysis (Pearson) and between T level by ANOVA.

Results

2405 men presented to PCAWs 2014 and 2015 and filled out the MADS questionnaire of which 1376 also had serum T levels determined. Mean age was 61.1 years (median 62, range 20-92) and mean T was 353.3 ng/dL (median 323, range 28-1319). Mean T with 95%CI for AODM, OS, EX and EF are shown in the table. There were no significant associations between T level and age and race. Responses to the MADS questionnaire and T<300 ng/dL resulted in positive correlation for AODM and OS (>20 lbs or less) 67.4% vs. 42.3% (OR 2.82, 95%CI 1.5-5.4, p=0.001), AA and OS vs no OS 62.5% vs. 42.8% (OR 2.22, 95%CI 1.22-4.03, p=0.007) and W/H, no EX, OS and low EF 60% vs 42.6% (OR 2.02 95%CI 1.14-3.61, p=0.015).

Conclusions

The study validates the use of the MADS questionnaire which identifies more than 60% of men with a T<300 ng/dL. Men with AODM and overweight by 20 pounds or more, AA men overweight by 20 pounds or more, and white/hispanic men who don't execise and are overweight by 20 pounds or more, have no or low confidence to get and keep and erection have a 2 fold or greater likelood compared to others of having a testosterone level < 300 ng/dL. This instrument can be utilized to screen for hypogonadal men. _x000D_ _x000D_

Funding

PCEC