Abstract: PD37-03
Sources of Funding: This research was supported by the Ministry of Science and Technology Taiwan (MOST 104-2320-B-016-012-MY3)_x000D_

Introduction

Androgen deprivation therapy (ADT) has been the mainstay treatment for advanced prostate cancer for more than seven decades. However, the relationship between ADT and the incidence of autoimmune diseases remains unclear.

Methods

A population-based nationwide cohort study of 17,168 patients diagnosed with prostate cancer between 1996 and 2013 was identified from the Taiwan National Health Insurance Research Database (NHIRD).Incident autoimmune diseases were ascertained at least 180 days after prostate cancer diagnosis. We used 1:1 propensity score–matched analysis ,multivariable-adjusted Cox proportional hazards models to investigate the association between ADT use and the risk of autoimmune diseases

Results

Of the 17,168 selected prostate cancer patients, 16,379 patients were met our inclusion and exclusion criteria, with 7,025 receiving ADT and 9,354 were no-ADT users. After 1:1 propensity score matching, there were 5,590 ADT users and 5,590 non-ADT users in the study cohort. During a mean follow-up period of 5.1 years, 457 patients were newly diagnosed with autoimmune diseases with 155 among ADT users and 302 among non-ADT users. Kaplan-Meier curves demonstrated a higher cumulative probability of remaining autoimmune diseases-free among ADT users (Figure 1). Compared to non-ADT users, ADT group was statistically associated with a decreased risk of autoimmune diseases (adjusted hazard ratio (HR) 0.63, 95%CI 0.52-0.76) after Cox proportional hazards models. More specially, ADT users had a decreased risk of Graves' disease (aHR 0.46, 95%CI 0.23-0.91), psoriasis (aHR 0.53, 95%CI 0.29-0.97), type 1 diabetes (aHR 0.33, 95%CI 0.17-0.63), and uveitis (aHR 0.51, 95%CI 0.26-0.97) (Table 1)._x000D_

Conclusions

The result of this study indicated that ADT use in patients with prostate cancer may decrease the risk of autoimmune diseases, especially in Graves’ disease, psoriasis, type 1 diabetes, and uveitis. Further studies are warranted to further investigation to obtain a better understanding between ADT and autoimmune diseases._x000D_

Funding

This research was supported by the Ministry of Science and Technology Taiwan (MOST 104-2320-B-016-012-MY3)_x000D_