Abstract: PD31-05
Sources of Funding: none

Introduction

There is a growing body of literature focusing on the impact PD on men's mental health and relationships. Aim: to assess the impact of PD on men's psychological and relationship health.

Methods

Patients were administered 3 validated questionnaires at presentation: the Self-Esteem and Relationship (SEAR) questionnaire includes 5 components, scores standardized by transforming onto a scale of 0-100, higher scores being more favorable; the Center for Epidemiologic Studies Depression Scale (CES-D), with moderate and severe depressive symptoms were defined as >14 and >21, respectively; the Peyronie's Disease Questionnaire (PDQ) 3 domains, psychological & physical symptoms, pain, symptom bother. Multivariable analysis (MVA) was used to explore predictors of baseline scores. Factors entered into the model included: age, sexual orientation, degree of curvature; duration of PD at presentation, the presence of non-curvature deformity, patient reported loss of length, stretched flaccid penile length, pain, penile instability, and ability to penetrate._x000D_ _x000D_

Results

Data from 204 men have been analyzed. Mean age = 56±12 years. Median PD duration = 9 months, mean curvature = 39±21 degrees, ED in 39%. 82% of patients were partnered with mean relationship duration=20 years. The mean penile length was 11 cms. 25% of the sample met the CES-D cut-off for depression: 13% moderate, 12% severe. Mean SEAR scores: total 54±24; sexual relationship 44±28 ; confidence 68±24; self esteem 68±25; overall relationship 70±30. These scores are similar to SEAR scores reported by men with moderate to severe ED. Mean PDQ scores: psychological & physical 11±6; pain 5±6; bother 7±4. Theses trends are similar to PDQ scores reported in the phase 3 Xiaflex studies (IMPRESS I & II). On MVA, higher CES-D scores were related to the inability to penetrate (β=0.18, p=0.04). Lower SEAR total scores were related to inability to penetrate (β=-0.30 p=0.01) and greater curvature (β=-0.25, p=0.04). Higher PDQ Bother scores were related to greater curvature (β=0.33, p=0.02), and marginally related to perceived loss of penile length (β=0.24, p=0.06) and inability to penetrate (β=0.22 p=0.09).

Conclusions

The data reinforce the significant prevalence of depression as well as psychosexual and relationship health in degree to men with ED. Common predictors of psychological and relationship variables were inability to penetrate, greater curvature, and perceived loss of penile length. Quality of life questionnaires into clinical practice might benefit some patients.

Funding

none