Abstract: PD22-03
Sources of Funding: none

Introduction

Oxidized regenerated cellulose (ORC) (Fibrillar®) is a topical absorbable hemostatic agent widely used in various urologic surgical procedures. Little is known regarding the impact of hemostatic agents in reducing risk of hematoma formation among men undergoing urologic prosthetic surgery. This study reports our initial experience with ORC as a hemostatic adjunct during inflatable penile prosthesis (IPP) surgery to determine the effect on postoperative drain output and subsequent complications.

Methods

Beginning in March 2016 ORC was placed as a pledget within the corporotomy closure of all men undergoing IPP insertion. Demographic, intraoperative, and postoperative parameters including cumulative overnight postoperative drain output were evaluated among cases with (March 2016 to present) and without ORC (December 2015 to March 2016) using an identical surgical technique by a single surgeon. Continuous variables were compared with the Mann-Whitney U test. Categorical variables were compared with Fisher's exact test.

Results

During the study period 61 men underwent IPP procedures. ORC was used in 27/61 cases (44%) causing a 38% reduction in median drainage output compared to the control group (40 mL vs. 65 mL; p=0.01). There was no difference in demographic, perioperative, or device-related characteristics. There were 2 IPP explantations secondary to infection, both of which occurred in the control group; one of which was directly related to hematoma formation. After controlling for other clinical features, the use of ORC (β -31, 95% CI: -61 to -1.3; p=0.04) was the only factor independently associated with a reduction in drain output.

Conclusions

This study suggests that the use of ORC pledgets during corporotomy closure of IPP reduces risk of hematoma formation.

Funding

none