Abstract: PD21-07
Sources of Funding: logistic support for the trail provided by lumenis.

Introduction

Flexible Uretero-Renoscopy (FRUS) is used in cases with large (>2 cm) renal stones, but the duration of surgery gets unduly prolonged and there is increase incidence of staged procedure.

Methods

A single-center prospective randomized double-arm study was performed to compare the high-frequency stone dusting and low-frequency stone breaking laser settings in FURS for the treatment of high-burden stone disease. Patients with stone size of >2 cm and <5 cm in the case of a single stone or the cumulative size of the largest stone diameters for stones ?5 cm in case of multiple stones were included. The primary end point was the procedure time.

Results

The planned enrollment included 15 patients in each arm of the study. After 6 patients were enrolled in each arm, an interim analysis was performed, and the results were reported to the human research ethics committee (HREC). The average number of stones in each renal unit was 1.53±0.7 and 2.01±0.8 in Groups 1 and 2, respectively. The average stone bulk was 4734±2387 cc and 5666.67±1032.796 cc in Groups 1 and 2, respectively. In Group 1, eleven patients (11/15) could be completely cleared of stones at the end of one month after a single-stage FURS using high frequency dusting protocols. In Group 2, (50%) the stones could be cleared after a single session of FURS using the low frequency stone breaking protocol at the end of one month in three patients.

Conclusions

A high-frequency stone dusting protocol was significantly more effective than a low-frequency stone breaking protocol for FURS in the treatment of high bulk renal calculus disease.

Funding

logistic support for the trail provided by lumenis.