Abstract: PD18-09
Sources of Funding: None.

Introduction

Goal of the study was a prospective patient-centered analysis of functional outcomes after radical prostatectomy (RP) in large cohort of 870 patients.

Methods

Patient-centered functional outcomes were assessed with the validated ICIQ-SF questionnaire and daily pad usage for the evaluation of stress urinary incontinence (SUI). Erectile dysfunction (ED) was assessed using IIEF5 score. In addition quality of life (QOL) in these patients was evaluated with the EORTC QLQ-C30 questionnaire. Statistical analyses included log-rank test, Mann-Whitney-Test and Kruskal-Wallis-ANOVA test (p<0.05).

Results

870 patients were included in the study. Median follow-up was 76 months. Regarding SUI, 63% stated that they needed no pads, 17% of patients needed one pad per day. 38% of patients reported of no incontinence (0 p. in ICIQ), 26% of included patients reported of a mild incontinence (1-5 p. in ICIQ). ICIQ score was significantly higher in older patients (75 y.; p<0.001) and improved statistically significant over time (3 mo. vs. 1, 2 and 3 years; all p<0.001). Regarding ED, an IIEF score of ?20 was reached by 39% of patients. The patients´ global impressions of their overall health (q. 29 EORTC QLQ-C30) resp. the subjective QOL (q. 30 EORTC QLQ-C30) were both high with median of 6 points. Younger patients (75 y.; p=0.011) showed a higher QOL score and the QOL score improved statistically significant over time (3 mo. vs. 1, 2 and 3 years; p=0.002, p=0.040 and p<0.001). In multivariate analysis time and tumor stage could be identified as independent risk factors on QOL score, IIEF-5 score, ICIQ score and pads per day for SUI with improving score over time (each p<0.001).

Conclusions

We provide a prospective patient-centered functional outcome analysis in a large cohort of patients after radical prostatectomy and highlight the importance of an appropriate counselling regarding the postoperative functional outcomes and their impact on QOL.

Funding

None.