Abstract: PD10-07
Sources of Funding: none_x000D_

Introduction

Prostate HistoScanning TM (PHS) is a novel ultrasound-based technology that uses computer-aided analysis to quantify tissue disorganization induced by malignant processes to visualize the position and extent of tumor. Objective of this study was to determine extent to which PHS can identify tumor foci that correspond to a volume of ? 0.50 mL.

Methods

Between November 2014 and May 2015,34 men underwent PHS before scheduled radical prostatectomy (RP). 3D-data required for PHS analysis were acquired by transrectal ultrasonography and analyzed using organ-speci?c tissue-characterization algorithms.PHS analysis results were compared with histology of the whole mounted prostate.

Results

A total of 204 sextants were studied in 34 patients. Prostate volume and PHS identified lesion volume were 13.49±13.85 mL and 3.10±2.06 mL respectively. PHS correlated well with step sectioned RP specimen tumor volume (Spearman’s coefficient of rank correlation=0.55, p = 0.007). Using the clinically accepted volume threshold of 0.50 mL- sensitivity, speci?city, positive and negative predictive values of PHS were 88.4%, 50%, 78.2% and 68%, respectively.

Conclusions

PHS has the ability to reliably detect cancer foci more than 0.5 mL within the prostate. Further exploratory studies are required to assess its role in the management of prostate carcinoma.

Funding

none_x000D_