Abstract: PD02-02
Sources of Funding: none

Introduction

The aim of this study was to elucidate the impact of pelvic organ prolapse (POP) repair on overactive bladder (OAB) symptoms in women with POP and the mechanism of de novo OAB. And we also tried to identify preoperative factors for persistent postoperative OAB symptoms.

Methods

A total of 106 patients with POP who underwent POP repair in our hospital were included and retrospectively analyzed. Each women had a urinalysis, pelvic examination, urodunamic study, MRI and answered a urinary questionnaire. OAB was defined by OAB symptom score (OABSS) , and POP severity was classified by POP Quantification. They were divided into clinically preoperative OAB group (n=47) and non-preoperative OAB group (n=59).

Results

In 47 preoerative OAB patients, OAB symptoms were improved after surgical treatment in 31 cases (65.9%). There were correlation between OAB improvement after POP repair and preoperative POP-Q stage (p=0.034?c.c 0.348 ), presence of para-vaginal defect (p<0.01?c.c 0.538). In 59 non-preoperative OAB patients, de novo OAB were observed in 5 cases (8.4%). There were correlation between de novo OAB appearance and hypertension (p<0.01?c.c 0.674 ).

Conclusions

Women with severe POP or para-vaginal defect who undergo surgical repair experience significant improvement in OAB symptoms after surgery, hyperextension of the bladder wall was considered to be the cause of OAB by stimulating the stretch receptors. Severe POP or para-vaginal defect are considered a predictor of improvement of OAB symptoms after POP surgery. In addition, bladder blood flow disturbance due to hypertension was possibly one of the causes of de novo OAB in POP patients.

Funding

none