Dynamic imaging of urine flow at bladder neck in rabitt during voiding using tracer by wreless capsule endoscope
Sources of Funding: none
Introduction
There was not yet report on visualizing flow at voiding from baldder neck in vivo. We vizualized urine flow from internal vew of baldder neck. using by wireless capsule endoscopes (WCEs) for cystoscopy at voiding in vivo.
Methods
Experimental evaluation of capsule cystoscopy was performed in a 5-kg farm rabbits(n=6). The capsule was inserted after incision of bladder. Images were continuously transmitted at a rate of four frames per second to a laptop computer and processed using proprietary software. Manipulation of the WCE within the bladder was performed using a set protocol. We measured the ability to deploy and manipulate the capsule within the bladder. Feasibility of capturing and retrieving images in real time was also assessed. We used air bubble(injection by syringe) and dye(intravenous administration of indigocarmine) as urine flow tracer.
Results
The WCE was efficiently deployed and manipulated within the bladder passively by manual. The entire bladder mucosa real-time image transmission and capture was visualized. The urine flow rotated clockwise from ventral to visceral at bladder neck during voiding. _x000D_ Fig.a): closed bladder neck before voiding, b)c) :air bubble rotated fom 12 to 3 at clock and d)sucked to internal urethra,no apparent of the air bubble._x000D_ Fig(A) :the dye was visualized on closed bladder neck before voiding_x000D_ Fig(B) :when bladder neck begun to open , the dye visualized a vortex with rotation clockwise like crescent moom._x000D_
Conclusions
By this device, urine flow could be visualized a vortex with rotation clockwise from ventral to visceral at the bladder neck mucosa during voiding.
Funding
none
Hideki Mizuno
Shigehiro Soh
Yasuhito Funahashi
Yoshihisa Matsukawa
Masanao Nakamura
Momokazu Gotoh