Login to Access Video or Poster Abstract: MP93-17
Sources of Funding: none

Introduction

Radical prostatectomy (RP) remains the mainstay therapy in localized disease. In recent years, minimally invasive, endoscopic RP (ERP) gained widespread use although its influence on patients reported health related quality of life (HRQOL) was not fully established._x000D_ _x000D_ To assess HRQOL in men subjected to extraperitoneal, endoscopic radical prostatectomy (EERP) and transperitoneal endoscopic radical prostatectomy (TERP) with extended pelvic lymph node dissection.

Methods

HRQOL surveys were completed at baseline, 3 and 12 months after surgery. The general and prostate-specific sections of HRQOL were assessed with Medical Outcomes Study 36 – Item Short Form (SF-36) and University of California, Los Angeles Prostate Cancer Index (UCLA – PCI) respectively._x000D_

Results

The surveys were returned by 126 (76%) and 111 (67%) men after 3 and 12 months, respectively. Adjuvant radiotherapy was performed in 10 (9%) patients. Only patients without adjuvant treatment (radiotherapy or hormonotherapy) were included in the analysis, resulting in a final study cohort of 101 patients (71 and 30 for the TERP and EERP, respectively). The median patients age in TERP and EERP group was 62.0 and 64 years, respectively. There is no significant difference QOL scores for the baseline, after 3 months and 12 months after operation in each group._x000D_ In the EERP group Mental Health improved over the baseline after 12 months. In the TERP group Mental health and Social functioning improved over the baseline after 12 months._x000D_ In the rest of domains QOL scores did not change after 12 months in both groups. For the baseline score, at 3 months and 12 months there was no significant difference between the EERP and TERP groups except for sexual function that was worse in the EERP group at baseline._x000D_ Urinary function, urinary bother, sexual function and sexual bother had not returned to baseline at 12 months in both groups. Bowel function and bother was not different after 12 months in each group. At 12 months after ERP 41 (58%) and 17 (54%) men did not use any pads for 24 hours in TERP and EERP group, respectively_x000D_

Conclusions

Endoscopic, extraperitoneal and transperitoneal radical prostatectomies with extended pelvic lymph node dissection do not alter patients reported health related quality of life. No significant differences were found between the two treatment groups. We could attributed that aggressive treatment of PCa do not more compromise HRQOL.

Funding

none