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Presentation and Treatment Outcomes of Ejaculatory Duct Obstruction

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Introduction

Ejaculatory duct obstruction (EDO), is either complete or partial and it affects 5% of infertile men. Complete obstruction occurs in up to 1% of the infertile male population while incomplete obstruction occurs in up to 4.4% of the infertile male population. _x000D_ _x000D_ EDO often presents with infertility. In some patients EDO is symptomatic and patients may present with: decreased force of ejaculate, pain on or after ejaculation, decreased ejaculate volume, haemospermia, perineal or testicular pain, low back pain and dysuria._x000D_ _x000D_ We set out to determine the presentation and treatment outcome of EDO._x000D_

Methods

A retrospective analysis of 54 patients diagnosed with EDO over the past 7 years._x000D_ Patients were evaluated by history, examination, semen analysis and trans-rectal ultrasonography (TRUS). Patients presenting with infertility also had hormonal profile and male reproductive genetic profile._x000D_ _x000D_ All patients had transurethral resection of the ejaculatory ducts (TURED) or TUR cyst deroofing for midline cysts. _x000D_

Results

The mean (range) patient age was 38(24-64) years. Twenty three patients (42%) presented with ejaculatory disorders, 20 patients (37%) presented with infertility, and 11 with pelvic pain or urinary symptoms. 9 (16%) of these men presented with both infertility and ejaculatory disorders._x000D_ _x000D_ The cause of EDO was congenital midline cyst in 30 patients (56%), idiopathic in 6 (11%), mullerian duct syndrome in 2 (4%), associated with unilateral vasal aplasia in 5 (9%), and ejaculatory duct obstruction associated with calculi in 11 (20%)._x000D_ Of the 33 patients with symptomatic EDO; 22(68%) had complete cure while 5 (22%) had persistence of symptoms and 6 men did not attend for their follow up appointments._x000D_ _x000D_ Semen parameters pre and post procedure were available for 26 men. Improvements were seen in 16 of these men; Mean (range) sperm count was 12.5 (0-75) x106/cc pre-operatively and 25 x106/cc (4 to 137) post TURED. Average semen volume increased from 0.9 to 3.7 mls and mean motility increased from 10% (0-45%) to 43%(14-68%). 10 men remained azoospermic suggesting an associated proximal obstruction._x000D_ _x000D_ Complications occurred in 7 patients (18%): epididymitis (3), chronic pelvic pain (1), retrograde ejaculation (1) and urine retention (2). _x000D_

Conclusions

EDO is an underdiagnosed cause of ejaculatory disorders. Excluding EDO is important in the management of patients presenting with ejaculatory disorders in addition to infertile males. _x000D_ _x000D_ It can be easily diagnosed by TRUS. TURED is an effective and safe treatment for EDO.

Funding

none

Authors
Pippa Sangster
Ayo Kalejaiye
Giovanni Chiriaco
Amr Raheem
Asif Muneer
David Ralph
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