Login to Access Video or Poster Abstract: MP89-07
Sources of Funding: None

Introduction

Hypogonadotropic hypogonadism is a rare disease for infertile patients. Generally, sperm can be obtained in ejaculate after medical treatment, but some patients can undergo testicular sperm extraction. The aim of the present study was to evaluate ART outcomes in men with hypogonadotropic hypogonadism.

Methods

A total of 119 ART cycles in 61 patients were evaluated in this study between January 2004 to August 2016. Hormone replacement therapy including human chorionic gonadotropin 5.000-10.000 IU weekly and human menopausal gonadotropin 150-225 IU weekly were given before ART cycles. ART cycles were planned when hormone levels were in eugonadotropic and/or sperm was observed in the ejaculate. ART cycles were divided into two groups according to sperm source as ejaculated (n=94) and testicular spermatozoa used (n=25). Total number of retrieved and metaphase II oocytes, fertilization, clinical pregnancy and life birth rates were compared between two groups. Additionaly, ART cycles were also evaluated in fresh (n=91) and frozen embryo (n=28) cycles.

Results

Male mean age and duration of infertility were 35.8±5.64 and 6.1±4.16 years, respectively.While ejaculated sperm was used in 94 (79%) cycles, testicular sperm was used in 25 (21%) cycles with persistent azoospermia despite hormonal treatment. Micro TeSe was performed on 16 patients (13.4%), and sperm was found in 13 of them. Therefore, the sperm retrieval rate with micro TeSe was 81.3% in hypogonadotropic hypogonadism. Compared parameters were given in Table 1._x000D_ While there was observed statistically significant difference in clinical pregnancy rate between two groups according to sperm source (p=0.017); there were not observed any statistical differences among other compared parameters. _x000D_ Additionally, the ART outcomes were evaluated in fresh and frozen embryo transfered ART cycles. In fresh and frozen embryo cycles, pregnancy rate was 48.4% and 42.9% and life birth rate was 34.1% and 25%, respectively. There were not observed statistical differences between these parameters (p>0.05). _x000D_

Conclusions

Patients with hypogonadotropic hypogonadism have high fertilization and pregnancy rates in both of fresh and frozen ART cycles. Although sperm retrieval rate is higher with micro TeSe, ejaculated spermatozoa can be used effectively for ART.

Funding

None