Login to Access Video or Poster Abstract: MP86-11
Sources of Funding: none

Introduction

The objective of this study was to characterize the status of psychological symptoms in Japanese men with late-onset hypogonadism (LOH) treated with testosterone replacement therapy (TRT)._x000D_ _x000D_ _x000D_

Methods

The psychological symptoms in 100 consecutive Japanese men with LOH undergoing TRT for at least 6 months were prospectively evaluated before and 6 months after the initiation of TRT using several written questionnaires, including Mini International Neuropsychiatric Interview (M.I.N.I.), Self-rating Depression Scale (SDS), Aging Male Symptom (AMS) score and the Medical Outcomes Study 8-items Short-Form health survey (SF-8).

Results

In these 100 patients, 69 men consulted our outpatient clinic with a chief complaint of psychological symptoms, such as depressed mood, lack of motivation, anxiety and irritation. The other 31 men were with a chief complaint of physiological or sexual symptoms. Before the introduction of TRT, 62 patients were diagnosed as being complicated with depression by M.I.N.I.. Although there were not significant correlations between serum testosterone level and all evaluated psychological questionnaires scores, including SDS, mind domain of AMS and mental component summary of SF-8, before the initiation of TRT, all these scores at 6 months after TRT significantly improved compared with those before TRT in these 100 patients. When divided these 100 men into 2 groups, with and without depression, there was no significant difference in serum testosterone level between these 2 groups before TRT. The psychological symptoms assessed by several questionnaires in this study were significantly severe in men with depression compared with men without depression. However, all evaluated psychological questionnaires scores at 6 months after TRT significantly improved compared with those before TRT even in men with depression.

Conclusions

TRT appeared to significantly improve the status of psychological symptoms in men with LOH, regardless of a complication of depression._x000D_

Funding

none