Login to Access Video or Poster Abstract: MP82-17
Sources of Funding: NSF China 81670695; China America Promotion Society for Medical Doctors (CAPs MD)

Introduction

Clinically, mid-urethral sling procedure has become a regular and popular treatment for stress urinary incontinence (SUI). However, it has limited improvement if intrinsic sphincter deficiency dominantly and/or co-existing serious urgency symptom. We applied a new neuro-modulative sling in an acute urinary incontinence rat model to test if it can improve the urinary incontinence and urinary urgency simultaneously.

Methods

The neuro-modulative sling made by sling mesh along with small silver wire electrodes which were connected to electrical stimulator with the free ends in the middle of sling for electrical stimulation. An acute mixed urinary incontinence animal model was made by bilaterally pudendual nerve transaction (PNT, n=21) or sham PNT (n=20) followed by potassium chloride (4M, KCl) or saline (control, 0.9% NaCl) bladder perfusion. Urodynamic testing performed to confirm the changing of the bladder contractions. Leak point pressure (LPP) was also tested during filling cytometry.

Results

With current above 10mA and frequency above 50Hz result in significantly increased LPP during electrical stimulation delivering to the neuro-modulative sling (p<0.05). The continuous electrical stimulation with bi-polar square wave at the parameters of frequency to 5 Hz and pulse duration to 150 ?s may decrease the increased bladder contractions significantly after PNT and KCl perfusion (p<0.01)._x000D_

Conclusions

The study demonstrated the neuro-modulative sling with different electrical stimulation parameters may improve mixed urinary incontinence in an acute animal model. Our future direction is studying its effects on a long-term animal model and possible complications if long-term implantation and use.

Funding

NSF China 81670695; China America Promotion Society for Medical Doctors (CAPs MD)