Login to Access Video or Poster Abstract: MP81-06
Sources of Funding: None

Introduction

Currently bariatric surgery is the most effective treatment for significant and sustained weight loss. Erectile and endothelial dysfunctions may share some common metabolic and vascular pathways that may be influenced by weight-loss. The aim of this study is to assess the effect of surgically induced weight loss on obese men with sexual dysfunction undergoing laparoscopic sleeve gastrectomy (LSG). We also aimed to analyse the proposed underlying mechanism associated with change in erectile function after weight loss by LSG.

Methods

Eighty two consecutive obese men who underwent a laparoscopic sleeve gastrectomy were followed for 12 months. All operations were performed by the same surgeon at a single institution. _x000D_ _x000D_ Patients were examined both before and after 12 months of LSG for biochemical tests; total serum cholesterol, triglyceride, C-reactive protein (CRP), interleukin-6 (IL-6) and endothelial nitric oxide synthase (eNOS) and for erectile function tests; International index of erectile function (IIEF) scores. _x000D_

Results

Eighty two men (mean age 39±14.6years, range 24–62; mean BMI 41.2± 4.8kg/m2) completed all pre- and postoperative questionnaires and biochemical tests. At 12 months the mean weight loss was 34.8?kg and the mean BMI decrease was 8.6?kg/m2._x000D_ Preoperatively, 67 (77%) men (mean age 40± 12.9 mean, BMI 42.2± 5 kg/m2) were sexually active. Erectile function was significantly improved (p=0.02). Men had a significant decrease in serum cholesterol and triglyceride levels. NOS activity showed a significant increase (P<0.02). In addition, our patients showed a statistically significant decrease in IL-6 levels and CRP compared with preoperative period (P<0.03 and P<0.01 respectively)._x000D_

Conclusions

A significant improvement of erectile function was documented among obese young men undergoing bariatric surgery. This improvement was documented both clinically by improvement in IIEF score postoperatively and biochemically through reduction of hyperlipidemia and amelioration of both endothelial function and inflammatory cytokines.

Funding

None