Login to Access Video or Poster Abstract: MP78-12
Sources of Funding: None.

Introduction

The purpose of this study was to investigate the correlation between Controlling Nutritional Status (CONUT) score and survival of patients with localized urothelial carcinoma of the upper urinary tract (UCUT) treated with radical nephroureterectomy (RNU).

Methods

We retrospectively enrolled 109 patients. The CONUT score was based on serum albumin level, lymphocyte count, and total cholesterol level. Receiver-operating characteristic curve analysis for relapse-free survival (RFS) was performed, and the maximum Youden index was used to set the cutoff value of CONUT score. According to this cutoff, patients were classified into two groups (i.e., high and low CONUT score). RFS, cancer-specific survival (CSS), and overall survival (OS) after RNU were compared, and predictors of survival were analyzed.

Results

For CONUT score, the area under the curve was 0.588 and the optimal cutoff value was 3. Twenty-five patients (22.9%) had high CONUT score. The CONUT score was not associated with the clinicopathological parameters. The patients with high CONUT score had significantly lower 5-year RFS, CSS, and OS than those with low CONUT scores (RFS: 46.7% vs. 66.0%; CSS: 25.7% vs. 71.7%; OS: 24.2% vs. 66.8%, all p < 0.05). Multivariate analyses, after adjustment for factors, including pT stage, pN stage and tumor grade, revealed that CONUT score was an independent predictor of CSS (hazard ratio [HR], 5.03; p = 0.0006) and OS (HR, 3.01; p = 0.0080), and a statistically marginal difference in RFS (HR, 2.15; p = 0.0513).

Conclusions

Preoperative CONUT score is a novel predictive biomarker in patients with localized UCUT treated with RNU.

Funding

None.