Login to Access Video or Poster Abstract: MP61-05
Sources of Funding: none

Introduction

The aim of this study is to evaluate urinary Carbohydrate Antigen 19-9 (CA19-9) levels in early detection of pyelonephritis and its relation with clinical course of the infection and inflammatory changes detected by DMSA.

Methods

Thirty-five patients with febrile UTI were included in this study as the case group and 30 children who had negative urine culture were nominated as the control group. Urine samples were collected from all participants. Children in case group also underwent complete history and physical examination, kidney and bladder ultrasonography, DMSA, urine analysis and culture. Urine CA19-9 was measured by an electrochemiluminescence enzyme immunometric kit and expressed in U/ml. That level was correlated with clinical factors during statistical analysis.

Results

A total of 65 children were included in this study (mean age: 3 ± 2.8, 12 male and 53 female). CA19-9 levels were significantly greater in the case group than controls (334.30 ± 308 versus 11.68 ± 5.68, P < 0.000). Urine cultures showed that E. coli was the cause of UTI in most cases. CA19-9 levels were significantly higher in the acute phase of febrile UTI and in children with recurrent febrile UTIs and kidney damage. A correlation was found between CA19-9 levels and temperature. No significant association was found regarding age, sex and urinary CA-19-9 levels.

Conclusions

This study suggests that urine CA19-9 level is markedly increased in pyelonephritis and has potential utility as a predictive biomarker. Also urine CA19-9 levels can be used as an early detection marker for pyelonephritis in children with UTI._x000D_ _x000D_

Funding

none