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Sources of Funding: none

Introduction

Although both therapeutic effects and adverse events of androgen deprivation therapy (ADT) are well known, serum lipid profile changes by ADT have quite recently been studied. ADT increases the risk for cardiovascular disease (CVD), which is affected by serum lipid profiles as the pathogenesis of atherosclerosis. Moreover, the low-density lipoprotein cholesterol (LDL-C) /high-density lipoprotein cholesterol (HDL-C) (L/H) ratio has been recognized as a strong risk predictor of CVD. The aim of this study was to investigate changes of serum lipid profiles and L/H ratio in prostate cancer (PC) patients who received ADT.

Methods

A prospective study assessed the changes of serum lipid profiles and L/H ratio using clinical laboratory variables among 68 PC patients treated with ADT for 6 months. The patients who did not take lipid-lowering drugs were divided into two groups based on L/H ratio less than 2.5 or not. Furthermore, patients who had a high risk of worsening L/H ratio after ADT were investigated.

Results

At 6 months after the start of ADT, serum levels of total cholesterol, HDL-C, and LDL-C increased significantly in both groups. On the other hand, L/H ratio increased significantly in the patients with pretreatment L/H ratio less than 2.5. On univariate analyses, systolic blood pressure (sBP, p =0.007), diastolic blood pressure (dBP, p =0.004), and HDL-C (p =0.012) were significantly associated with worsening L/H ratio. HDL-C was found to be an independent predictor of worsening L/H ratio on multivariate analysis (Odds ratio:1.11, p =0.03).

Conclusions

PC patients treated with ADT have a higher risk of worsening L/H ratio. These findings suggest that clinicians can identify and manage PC patients more effectively with a greater risk of worsening L/H ratio after ADT.

Funding

none