Login to Access Video or Poster Abstract: MP57-14
Sources of Funding: none

Introduction

The majority of deaths from prostate cancer are among men with metastatic (mPCa) and/or castration-resistant prostate cancer (CRPC). Long-term outcomes of these patients are generally not well characterized as data from most randomized trials were censored at interim analysis. The objective of our study is to investigate factors associated with survival in a dedicated outpatient clinic. Variables of interest included body mass index (BMI) and comorbidities such as diabetes (DM) at diagnosis._x000D_

Methods

All patients with mPCa and/or CRPC seen in the Vanderbilt Comprehensive Prostate Cancer Clinic were eligible. Demographic and pathologic information were extracted from the electronic record under IRB-protocol. Overall survival (OS) was estimated using the Kaplan-Meier method. Multivariate analyses using Cox proportional hazard models were also performed. _x000D_

Results

Complete clinicopathological data was available for 79 patients. Median follow-up was 7.1 years, 18/79 (22.7%) patients had pre-existing DM and median BMI was 28.5 kg/m2. Disease characteristics included 39 (49.3%) with Gleason 8 or greater on biopsy, median PSA of 14.91, and 20 (25.3%) presenting with M1 disease. Preexisting DM was associated with worse 5-year mortality (22.9% vs. 9.3%, p=0.042). There was a trend towards significant association of BMI >30 kg/m2 with lower 5-year mortality (6.1% vs. 13.9% BMI <30 kg/m2, p=0.052). Multivariate analysis showed BMI is independently associated with OS (HR 0.83 (95% CI 0.69-0.98), p=0.036) correcting for age, DM, stage, PSA and Gleason score at diagnosis. _x000D_

Conclusions

We show BMI and DM are associated with survival for patients who develop advanced prostate cancer. Furthermore, BMI is significantly associated with survival in this cohort. Our findings should prompt further analysis of the impact of clincopathlogic factors and treatment response in a larger cohort. _x000D_

Funding

none