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Outcome analysis of patients with Peyronie's disease who elect for non-invasive management

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Sources of Funding: None

Introduction

Peyronie's disease (PD) affects approximately 5% of men and has numerous proposed treatments. Invasive management options include surgical or injectable therapy, while penile traction therapy with vacuum erection device (VED) represents a non-invasive approach. The objective of the present study is to assess outcomes for patients with PD who opt for non-invasive management.

Methods

Retrospective analysis of clinical data was performed for patients assessed for PD between July 2014 and August 2016 who were followed for at least 3 months and opted for non-invasive therapy. All patients were instructed to initiate traction therapy with VED for 10 minutes twice per day. Patients were assessed for degree of Peyronie's deformity and erectile function (SHIM score) at initial and subsequent encounters._x000D_

Results

In all, 35 patients met the inclusion criteria. The mean [standard deviation (SD)] age was 58 (10.7) years, and the mean (SD) duration of PD prior to assessment was 24 (15.6) months. The mean (SD) duration of follow up was 11 (5.9) months. At follow-up, 24 men had not purchased a VED. Among patients who did not use a VED, 6 showed improvement, 16 remained stable and 2 had worsening curvature. Overall, the control group did not have a significant change in curvature, with a mean improvement (SD) of 2.5 (9.1)° (p=0.10). All 11 men who initiated VED traction therapy had an improvement in curvature with a significant mean (SD) improvement of 29.6 (17.1)° (p<0.001). Using linear regressions, we found a significantly greater percentage reduction in penile curvature with decreasing patient age for the VED group (r = 0.66, p = 0.03). No such correlation was identified in the control group (r = -0.13, p = 0.57). Changes in SHIM scores did not vary significantly between groups. No complications were noted.

Conclusions

In patients who opt for non-invasive management of PD, VED traction therapy provides improved curvature resolution compared to those who do not use such a device. Furthermore, VED therapy is potentially more effective in relatively younger patients._x000D_

Funding

None

Authors
Landan MacDonald
Kyle Lehmann
Luke Armstrong
Gavin Langille
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