Login to Access Video or Poster Abstract: MP56-06
Sources of Funding: None

Introduction

To examine our early experience on the efficacy and safety of CCH for PD patients.

Methods

Between June 2014 and September 2016, we evaluated and treated 52 patients with stable PD Curvature (predominately dorsal with palpable plaque) Our protocol consists of 3 month cycles it begins with a one CCH injections for the first 2 weeks giving a total dose of 0,58 mg, following by modeling under local anesthesia during the initial month and two months of "Triple Therapy" - tadalafil 5mg daily, pentoxifiline 400mg twice a day and 6-8 hours of penile traction therapy.

Results

The cohort mean age was 56 (43-71) years with a mean curvature of 54º (30-90) degrees. During our mean follow up of 10 months, we noted significant clinical improvement in in PDQ bother scores from 7.5 to 4.2. Likewise there was PDQ symptoms improvement from 11.5 to 7.8. There was a median of 2 cycles (1-4) per patient and 75% had positive responses after 2 cycles. The mean curvature reduction or degree improvement per cycle was 14 grades (11-18). Five patients (9%) have required surgery for complete PD resolution. All side effects were mild, except two cases of plaque rupture, managed conservatively, with very good clinical outcome.

Conclusions

Using our modified-protocol combining CCH therapy, modeling and standard conservative therapy we achieved these promising preliminary results.

Funding

None