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Towards Standardization of Protocols for Intralesional Collagenase Clostridium Histolyticum (CCH): Survey Results of SMSMA Membership

Login to Access Video or Poster Abstract: MP56-05
Sources of Funding: None

Introduction

CCH is the only FDA approved medical treatment for peyronie's disease. Variable protocols exist regarding pretreatment evaluation, patient selection, procedural therapy and post treatment protocols. The objective of this study was to identify practice patterns of SMSNA members with respect to CCH treatment to better standardize protocols for safety and efficacy.

Methods

A 10 question survey was sent via survey monkey to SMSNA membership in November 2016. Questions solicited frequency of administration, use of formal peyronie's disease questionnaires (PDQ), use of other intralesional therapies, preprocedure objective measurements, remeasuring frequency, post procedure local wound care, use of post op modeling and stretch options. Off label use and in office and home modeling protocols were queried as well.

Results

85% of respondents typically inject at least 10 CCH injections/per month._x000D_ _x000D_ Refer to table 1 for questions_x000D_ _x000D_ Off label use of CCH included ventral (17%), pain only (9.4%), curvature of less than 6 months duration (59%), unstable active disease (28%) and conformational architectural changes (78%). 45.8% will do only in office modeling once and all subsequent is done at home, while 30.5% do in office modeling and home modeling with each cycle._x000D_

Conclusions

Most SMSNA members that took the survey used intralesional CCH frequently. Most do NOT use a Peyronie's PDQ prior to therapy and most measure curvature prior to therapy with intracavernosal injection, but not after each cycle. 62% offer other intralesional therapy in their practice. As November 2016, most did not use a stretching device or vacuum erection device in the modeling process. Most commonly, in office modeling is usually done just ONCE in the office. Many SMSNA members use CCH for off label indications such as active disease, prior to 6 month duration and ventral curvature. This data offers the information about the variety of protocols utilized by active CCH users.

Funding

None

Authors
Campbell Bryson
Stanton Honig
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