Login to Access Video or Poster Abstract: MP37-18
Sources of Funding: none

Introduction

Cushing&[prime]s syndrome is caused by prolonged and excessive exposure to cortisol. It is suggested that this chronic exposure is associated with comorbidities contribute to poor quality of life. The purpose of this study was to evaluate patient-reported health related quality of life (HRQOL) of Cortisol producing adrenocortical adenoma (CPA) in comparison with that following Non-CPA (NCPA).

Methods

A total of 24 and 62 patients who underwent laparoscopic adrenalectomy in CPA and NCPA between January 2012 and September 2015 were included in the study. We assessed general HRQOL with the Short Form 8 (SF-8) instrument. We administered the SF-8 questionnaires at pre-operative baseline, and at 3, 6, 9, 12, 18 and 24 months after surgery. The impact of changes in two measurements of the physical (PCS) and mental (MCS) components summary scores of the SF-8 was evaluated in the prospective and longitudinal study.

Results

There was no significant inter-group difference in patient characteristics between the CPA and NCPA groups. Baseline PCS was significantly lower in the CPA than the NCPA group (43.6 vs. 49.0, p=0.0075). Subsequently, the PCS score was significantly lower in the CPA group at postoperative 3, 6, 9, 12 month. The PCS score was increased in the CPA group and there was no significant difference between both groups at postoperative 18 (48.1 vs. 50.2, p=0.1202) and 24 (48.0 vs. 50.8, p=0.3625) month (Fig. 1A). However, in baseline MCS score, there was no significant difference between both the CPA and NCPA group (43.7 vs. 45.6, p=0.3957).The MCS score in both groups was gradually increased and there was no significant difference between both group in all postoperative points (Fig. 1B).

Conclusions

The patients with CPA were improved in not the mental but the physical component after postoperative 18 months. Our study suggests that laparoscopic adrenalectomy contribute to improvement of HRQOL in the physical function.

Funding

none