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Does the stump size in vasovasostomy can be a predictive factor to improve the outcomes of semen analysis associated with vasal patency?

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Sources of Funding: none

Introduction

Vasal patency, defined as the return of sperm in the ejaculation after the vasectomy reversal, is considered the best parameter for comparing the outcome of vasovasostomy. Post-vasectomy stump can be thought that it is also a factor to influence vasal patency. Thus, we evaluated the preoperative and intraoperative factors including post-vasectomy stump associated with vasal patency after vasovasostomy.

Methods

From February 2000 to 2016, we retrospectively reviewed 139 consecutive vasovasostomy procedures performed by a single surgeon. Excluding 55 patients (39 has lost follow up visiting and 16 refused semen analysis or failed to collect semen), 84 patients who performed semen analysis at 1 month after surgery were enrolled in this study. Vasal patency was represented by variables of semen analysis such as motility, morphology and the number of spermatozoa. The size of stump was measured by its length and diameter. The correlations between semen analysis and clinical variables including vasal obstruction interval, leukocyte differential count, and median size of bilateral stump were analyzed in univariable and multivariable method.

Results

The mean age (±SD) was 32.1±0.8 years and mean obstructive interval was 7.8±0.6 years. Clinical variables including vasal obstruction interval, leukocyte differential count and length of stump were no statistically significant association with semen analysis parameters. However, the diameter of stump was positively correlated with motility and morphology of semen analysis (rho=0.474, p<0.0001 vs rho=0.349, p=0.001). In linear regression model, diameter of stump was sole independent factor associated with motility of semen (B=27.843, p=0.003).

Conclusions

Our findings demonstrated that increased stump diameter was improved the outcomes of semen analysis after vasovasostomy. However, additional prospective studies with larger numbers of patients should be done to further define its clinical significance.

Funding

none

Authors
Phil Hyun Song
Jae Young Choi
Young Hwii Ko
Ki Hak Moon
Hee Chang Jung
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