Login to Access Video or Poster Abstract: MP28-12
Sources of Funding: none

Introduction

To assess an association between the increased risk of biochemical recurrence and lymphovascular invasion in T3 margin positive or negative patients and its association with lymph node metastasis.

Methods

1634 patients who underwent radical prostatectomy from 2005 to 2014 were selected. Patients with bone or distant organ metastasis at the time of operation were excluded. Survival analysis was performed to assess biochemical recurrence, bone metastasis and mortality risks by Kaplan-Meier analysis and multivariate Cox proportional hazard regression. Odds of lymph node metastasis were evaluated by Logistic regression.

Results

LVI was detected in 118 (7.4%) patients. The median follow-up duration was 33.1 months. In the Kaplan-Meier analysis, lymphovascular invasion was associated with significantly shorter biochemical recurrence free survival (39.3 vs. 82.5 months, p<0.001), bone metastasis-free survival (134.4 vs. 156.7 months, p=0.001) and cancer specific survival (122.7 vs. 152.6 months, p=0.034). When stratified by T stage and resection margin status, lymphovascular invasion resulted in significantly shorter biochemical recurrence-free duration in T3 patients with and without positive surgical margin (p=0.008, 0.005, respectively). In the multivariate Cox regression model lymphovascular invasion resulted in 1.4-fold risk increase (95% CI 1.05-1.75, p=0.031).Lymphovascular invasion was revealed to be strongly associated with lymph node metastasis in the multivariate Logistic regression (OR 4.26, 95% CI 2.07-8.79, p<0.001).

Conclusions

Lymphovascular invasion increased the risk of early recurrence in T3 patients regardless of margin status, by accelerating the metastasis.

Funding

none