Login to Access Video or Poster Abstract: MP21-12
Sources of Funding: Howard J Cohen Foundation

Introduction

Health related quality of life (HRQOL) after radical cystectomy and ileal conduit (RC-IC) is not well quantified at the population level. Given the large extirpative nature of the surgery combined with stoma creation, this is a life-changing event for patients. We evaluated post-RC-IC HRQOL in patients with bladder cancer (BC) compared with non-cancer controls and colorectal cancer (CRC) patients undergoing proctocolectomy with colostomy using SEER-Medical Health Outcomes Survey (MHOS) data._x000D_

Methods

SEER-MHOS data (1998-2013) was used to identify patients with BC and CRC diagnoses and survey data available post diagnoses. 196 BC patients undergoing RC-IC were propensity score matched 1:5 to non-cancer controls (N=980) and compared with 154 CRC patients undergoing proctocolectomy with colostomy. Differences in mental and physical composite scores (MCS and PCS, respectively) were compared between groups. MCS and PCS scores are normalized on a 0-100 scale where 50 represents US population mean. _x000D_

Results

RC-IC patients, compared with matched controls, had significantly lower PCS (35.9 vs. 40.2, p<0.001), physical functioning (52.6 vs. 62.4, p<0.001), role physical (41.2 vs. 54.0, p<0.001), social functioning (69.7 vs. 76.3, p=0.006), vitality (51.1 vs. 56.3, p=0.005), and general health (51.8 vs. 62.0, p<0.001). MCS and mental health subscale scores did not differ between groups. Comparing RC-IC patients with CRC patients, female gender (26 vs. 38%, p=0.01) and inflammatory bowel disease (6% vs. 14%, p=0.005) were more common in CRC patients. MCS, PCS, and HRQOL subscales did not differ between RC-IC and CRC patients. Among a subset of RC-IC patients with both pre and post-surgical data (N=46), PCS (p=0.002), physical functioning (p=0.04), social functioning (p=0.02), and general health (p<0.001) declined significantly._x000D_

Conclusions

RC-IC patients have worsened HRQOL than non-cancer controls. However, HRQOL of RC-IC patients was similar to that of CRC patients undergoing proctocolectomy with colostomy. Further longitudinal study is needed to better quantify HRQOL in RC-IC._x000D_

Funding

Howard J Cohen Foundation