Login to Access Video or Poster Abstract: MP19-15
Sources of Funding: none

Introduction

Although both hyperuricemia and uric-acid (UA) stone are potential risk factors for Chronic Kidney Disease (CKD), it remains unclear which factor has much more worse effects on renal function. We accessed the influence of hyperuricemia on impaired renal function in patients with UA stone components in comparison with community-dwelling population.

Methods

Between 2010 and 2014, we treated 1793 consecutive patients with urolithiasis in our hospital, and identified stone components available 473 patients. Of those, 123 patients with UA stone were included in the present study. Age, sex, and serum UA concentration adjusted control subjects were selected from 3089 community-dwelling population in each group by propensity-score matching (2 :1). Subjects were divided into two groups; hyperuricemia or non-hyperuricemia groups according to the serum UA concentrations (UA-low: < 7.0or UA-high: ?7.0 mg/mL). We compared renal function between the UA stone and control subjects in each group. The renal function was evaluated as estimated glomerular filtration rate (eGFR). The independent risk factor for impaired renal function were investigated by multivariate logistic regression analysis.

Results

We selected pair-matched 166 control subjects and 83 UA stone patients for serum UA-low group. Similarly, 68 control subjects and 34 UA stone patients for serum UA-high group. _x000D_ UA stone patients had significantly lower in eGFR (P<0.01) compared with control subjects regardless of serum UA concentrations. Multivariate logistic regression analysis revealed that age, past-history of cardiovascular disease, serum UA, and stone former were significant factors for stage 3 CKD. UA stone component had 3-fold chance to develop stage 3 CKD than serum UA concentration._x000D_

Conclusions

Uric acid stone components may strongly influence on renal function deterioration than hyperuricemia.

Funding

none