Login to Access Video or Poster Abstract: MP17-17
Sources of Funding: Veterans Administration

Introduction

Agent Orange exposure (AOe) has been demonstrated to be associated with an increased risk of prostate cancer (CaP). However, it is unknown whether AOe also increases the development of benign prostatic enlargement (BPE). The objective of this study was to determine the association between AOe and BPE by evaluating prostate volume in a US Veteran Cohort.

Methods

Risk factors including clinic-demographic and laboratory data from veterans who had undergone a initial prostate biopsy that was negative for cancer detection were collected. The primary outcome was the calculated prostate volume as determined by transrectal US. Prostate volume of AOe veterans relative to unexposed veterans was compared using univariate and multivariate logistic regression. Patient age, AOe, maximum PSA prior to biopsy, and BMI were included in the multivariate analysis.

Results

Of 1821 veterans undergoing an initial negative prostate biopsy 7% (129) had documented AOe. Age, BMI and maximum PSA were all significantly correlated with increasing prostate volume (p=<0.01 for each). On univariate and multivariate analysis there was no significant association between AOe and prostate volume as measured by US.

Conclusions

These results indicate AOe is not associated with an increase in prostate volume in a US veteran cohort undergoing an initial negative prostate biopsy. Despite its relationship with malignant growth of the prostate, AOe does not appear to be associated with BPE.

Funding

Veterans Administration