Login to Access Video or Poster Abstract: MP13-18
Sources of Funding: none

Introduction

To investigate the reference ranges for prostate volume (PV) and annual PV change rate, and to clarify the risk factors for the development of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) in healthy Korean men.

Methods

A total of 11,222 healthy men who received transrectal ultrasonography at our hospital for a routine health check-up were included. Those with prior biopsies or surgery for prostate disease, or with BPH medication were excluded. BPH/LUTS was defined as International Prostate Symptom Score (IPSS)≥8 points and PV ≥30 mL.

Results

The prostate-specific antigen (PSA) level, PSA density, PV, transitional zone volume (TV), and transitional zone index (TZI) increased significantly with age. The annual PV growth rate was 0.48 cm³/year. Body mass index, PSA, basal metabolism, fat mass, apolipoprotein A-1, high-density lipoprotein, aspartate aminotransferase, creatine, and urine pH were statistically associated with PV. PSA, fat mass, apolipoprotein A-1, creatine, and urine pH were significant predictive factors for both PV and TV. _x000D_ For men aged >40 years without prostate cancer history and treatment for BPH/LUTS, TZI (Hazzad ration (HR) =1.02, p = 0.001), total IPSS (HR = 1.04, p = 0.004) and alpha-fetoprotein (AFP) (HR = 0.86, p=0.040) were significant risk factors for the development of BPH/LUTS within 5 years._x000D_

Conclusions

This study showed that the TZI, total IPPS, and AFP were the major factors for the development of BPH/LUTS within 5 years in healthy Korean men.

Funding

none