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Risk factors of weak detrusor function in benign prostate hyperplasia patients: Determining a prognostic factor from urodynamic findings.

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Sources of Funding: none

Introduction

Benign Prostate Hyperplasia (BPH) is a major cause of Lower Urinary Tract Symptoms (LUTS) in men and surgical treatment is often required. However, due to long terms of difficulty, some patients show very weak detrusor functions. The aim of this study is to determine risk factors of low detrusor function._x000D_

Methods

We retrospectively reviewed 345 patients who were clinically diagnosed as BPH and videourodynamic studies (V-UDSs) was performed between 2008 and 2016. Age, prostate volume, post-voided residual urine (PRV) were evaluated. As the UDS parameters, mean bladder compliance, mean abdominal leak point pressure, Qmax, and Pdetmax were evaluated. The Schafer&[prime]s nomogram was used to evaluate the obstruction of lower urinary tract. The correlations among age, prostate volume, and V-UDSs findings were evaluated to determine the causal factor of weak detrusor function. The results of V-UDSs were compared among the groups. Spearman's rank correlation coefficient was used to evaluate the correlations. UDS findings were compared among the divided groups using unpaired t-tests.

Results

The mean value of prostate volume was 39ml. Mean PVR was 97ml and 102 patients had more than 100ml of PVR. During the filling phase 79 patients had detrusor overactivity (DO). 70 patients showed decrease in urinary sensation. As the result of Schafer`s nomogram, 254 patients had a stronger obstruction than grade 3 and 102 patients had a lower detrusor function than weak. Patients who had DO had a tendency of weak detrusor. Although the values of age and prostate volume did not show a correlation with UDSs findings including obstruction and weak detrusor, age and detrusor, prostate volume and obstruction showed a correlation(Fig 1). Compared by age, 78 years old was a cut off of weak detrusor (Fig 2.3).

Conclusions

From this study, high age and the presence of DO was a risk factor for weaker detrusor. Elderly who have DO may need surgical treatment in an early stage.

Funding

none

Authors
Tetsuichi Saito
Takashi Nagai
Tomonori Minagawa
Teruyuki Ogawa
Osamu Ishizuka
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