Login to Access Video or Poster Abstract: MP09-15
Sources of Funding: none

Introduction

To use antimuscarinics in BPH patients with storage symptoms has become a common practice. TURP may be needed in a part of these patients and some still need to stay on antimuscarinics after surgery. This study investigates the post-operative use of antimuscarinics in BPH patients with storage symptoms requiring antimuscarinics before surgery by analyzing a nationwide health insurance database.

Methods

A urology dataset including 3,431,366 individuals was selected from the National Health Insurance Research Database (NHIRD) of Taiwan for the year 2006 to 2010. The claim data was used for the study. Exclusion criteria were patients with prostate cancer or bladder cancer, those with co-morbidities which might present with LUTS, and those who had underwent procedures which might cause urinary retention. We identified 2,224 patients receiving antimuscarinics within 6 months prior to TURP and have been followed for more than one year after surgery. The post-operative use of antimuscarinics was serially investigated quarterly in terms of the percentage of patients continuing antimuscarinics.

Results

In 2,224 patients, 519 patients (23.3%) had AUR while using antimuscarinics before TURP. The percentage of patients continuously using antimuscarinics after TURP decreased significantly from the first quarter (26.4%) to the fourth quarter (10.8%) and then plateaued. The patients who did not suffer from pre-operative AUR had higher percentage to continuously use antimuscarinics post-operatively. Significant differences were observed in the first 3 quarters post-operatively. The differences were more pronounced in patients with larger prostate resection weight (≥15gm). When identifying patients with uninterrupted follow-up on an annual basis, the trend was similar. (Fig.)

Conclusions

For BPH patients with storage symptoms requiring antimuscarinics, the continuous use of antimuscarinics after TURP decreased significantly from the first quarter to the fourth quarter and then plateaued. More patients continuously used antimuscarinics post-operatively in those who did not suffer from pre-operative AUR than those who did. The difference was more obvious in patients with resection weight of prostate≥15gm.

Funding

none