Introduction

Both estimated split renal function measured by DTPA renography and kidney volume measured by MDCT can be used to predict postoperative renal function in kidney donors. We compared predicted post donation eGFR which was estimated by split renal function and renal volume with measured eGFR.

Methods

From January 2013 to May 2015, a total of 303 living kidney donors were analyzed. All donors underwent preoperative DTPA renography and MDCT scan. Bilateral renal cortex volume was measured by 3-dimension MDCT(Fig 1.). We estimated DTPA-eGFR(Remained split renal function(%) x preoperative eGFR) and Vol-eGFR (remained renal volume/total renal volume (%) x preoperative eGFR) and analyzed with DTPA-eGFR, Vol-eGFR and MDRD eGFR(1 week, 1 month, 3 month, and 6 month postoperatively). Also, we compared DTPA-eGFR and Vol-eGFR with ?eGFR.

Results

The mean value of DTPA-eGFR was 52.97±10.32 (ml/minute/1.73 m2) and Vol-eGFR was 51.26±10.26 (ml/minute/1.73 m2). Predicting dominating side was not agreed in 113/303 (37.3%). The MDRD eGFR showed a statistically significant correlation with total renal volume, DTPA-GFR and Vol-eGFR (p<0.001; Table1). ?eGFR shows significant correlation with total renal volume, DTPA-eGFR and Vol-eGFR(p<0.001). There were 101 patients who were eGFR less than 60ml/minute/1.73m2 at 6months after donor nephrectomy. Receiver operating characteristic (ROC) was performed to predict possibility of eGFR less than 60ml/minute/1.73m2 at six months with DTPA-eGFR and Vol-eGFR. DTPA-eGFR (AUC=0.858 p<0.001), and Vol-eGFR (AUC=0.878 p<0.001) could predict CKD III at 6 months (Figure1).

Conclusions

MDRD eGFR, Vol-eGFR, and DTPA-eGFR showed a statistically significant correlation. Moreover, Vol-eGFR and DTPA-eGFR were observed high prediction ability for CKD III at six months. In conclusion, Vol-eGFR was good predictive value for renal function recovery, and thus MDCT might substitute for DTPA renography in planning donor nephrectomy.

Funding

none