Login to Access Video or Poster Abstract: MP03-15
Sources of Funding: none

Introduction

To evaluate the cancer detection rate in negative multiparametric magnetic resonance imaging (mp-MRI) patients who accept the first time prostate biopsy. To analyze the potential influential factors of prostate cancer diagnosis.

Methods

The records of men undergoing prostate biopsy were retrospectively collected between July 2011 and June 2016. The PI-RADS score was used to evaluate the prostate imaging according to the European Society of Urological Radiology (ESUR) guideline and PI-RADS 1~2 was defined as negative. Finally, 196 patients were MRI negative. All the patients accepted T1, T2 and DWI image. Part of them had DCE image.The mean diagnosis age is 66.6±9.0yrs, and the median PSA is 7.44ng/ml.All patients accepted the transrectal ultrasound guided systematic 12-coreprostate biopsy._x000D_ Statistical analysis was carried out with the SPSS 19.0 computer package. A P value<0.05 was considered statistically significant._x000D_

Results

There were 196 patients enrolled, with the mean diagnosis age 66.6±9.0yrs, and the median PSA 7.44ng/ml. Of the 196 patients, there were 42(21.4%) diagnosed with prostate cancer, of which, 30 were clinically significant.The negative predictive value (NPV) was 78.6% for prostate cancer, and 84.7% for clinically significant prostate cancer.(a_image, b_image)_x000D_ Age and serum PSA were related with positive diagnosis. Patients over 70yrs was associated with a 2.4-fold higher risk for prostate cancer, which was 1.47 when patients were divided according to the PSA level of ≤4ng/ml, 4~10ng/ml, 10~20ng/ml and >20ng/ml.(c_image)

Conclusions

Clinical significant prostate cancer may exist in negative MRI patients in first time biopsy. The age and PSA level relate to the cancer detection rate.

Funding

none