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Sources of Funding: none

Introduction

Objective of the study was to investigate whether the effectiveness of GreenLight XPS (GL-XPS) laser Photoselective Vaporization Prostatectomy is different in patients with or without chronic 5-Alpha-Reductase Inhibitors (5ARI) therapy._x000D_

Methods

We retrospectively evaluated prospectively collected 12 months data from the multicenter GOLIATH study regarding the 136 patients with benign prostatic hyperplasia (BPH) treated by PVP with the GL-XPS Laser System. A total of 36 patients were on chronic 5ARI therapy while 100 were not. The two groups were compared with respect to lasing density defined as kilojoules of energy applied per gram of prostate volume, prostate volume and Prostate Specific Antigen (PSA) reduction from baseline, symptom score change from baseline and uroflowmetry parameters improvement._x000D_

Results

The two groups were largely similar at baseline. Mean prostate volume was 51.7 and 47.5 g in the group taking 5ARI and the group not, respectively. Lasing time and energy used were also greater in that group (50.5±22.4 min vs 42.4±20.4 min; 269.2±138.9 kJ vs 219.2±124 kJ). Energy delivered per prostate volume was greater in the group taking 5ARIs but the difference was not statistically significant (5.5±3.1 kJ/g vs 4.8±2.3 kJ/g, p = 0.185). No statistically significant differences were observed postoperatively in the two groups regarding prostate volume reduction, PSA decrease, improvement in symptom score and uroflowmetry parameters (Table 1)._x000D_

Conclusions

Twelve-month efficacy outcomes and lasing efficiency were not statistically significantly different between the group taking 5ARI and the group not taking pharmaceuticals. 5ARI do not reduce the ability to treat patients with the GreenLight XPS laser system._x000D_

Funding

none