Abstract: FRI-14
Sources of Funding: None

Introduction

Introduction: Throughout centuries of publications, different names and varied implications have accompanied the use of the term female prostate, an otherwise small anatomic region in women. As a result, many deny the existence and functional role of the female prostate in women’s sexual health. In reviewing past medical literature, we came across reports of the existence of the female prostate from the early days of the Kama Sutra. Scholars then discussed the homologous female prostate as a distinct organ within the female pelvis. Similarly, in 300 BC Herophiles identified the prostate gland during his human dissections and claimed this organ to be an anatomical component of both male and female reproductive anatomy. In 1672 Reignier de Graaf is credited with the first anatomical depiction of prostatic tissue surrounding the mid-urethra in women. Three centuries later Grafenberg described the role of the female urethra and surrounding prostatic tissue in orgasm.

Methods

Methods: A literature search was performed using the keywords "female prostate", "Skene's gland", "peri-urethral gland", and "G-spot". Over 200 publications were found based on relevance. Categories for analysis included anatomy, physiology, embryology, pathology, neural innervation, adenomatous and cancerous changes, and orgasmic potential. _x000D_

Results

Results: More than 60 publications were included for review and analysis. Since 400 BCE scholars have proposed the existence of sexually sensitive homologous "female prostate" peri-urethral anterior vaginal wall tissue. Contemporary researchers have characterized “female prostate” exhibiting glandular and secretive elements identical to male prostate via immunohistochemical studies with prostate specific antigen (PSA), prostate specific acid phosphatase, androgen receptors, biochemical analyses of PSA and creatinine in female ejaculate as well as three-dimensional modelling and waxy casts. _x000D_

Conclusions

Conclusion: "Female prostate" is embryologically and physiologically identical to male prostate. In some women, stimulation of "female prostate" via the anterior vaginal wall results in orgasm, analogous to stimulation of the anterior wall of the rectum resulting in orgasm in some men. The female prostate is not simply an incidental, vestigial organ; injury during surgical procedures may have clinical consequences, as peri-urethral anterior vaginal wall tissue possesses neurally-mediated sexually functional attributes. Despite skepticism, its existence is supported by extensive, reliable contemporary evidence._x000D_

Funding

None